Aluminium in PDB 3hb1: Crystal Structure of Ed-EYA2 Complexed with ALF3

All present enzymatic activity of Crystal Structure of Ed-EYA2 Complexed with ALF3:
3.1.3.48;

The structure of Crystal Structure of Ed-EYA2 Complexed with ALF3, PDB code: 3hb1 was solved by S.K.Jung, D.G.Jeong, S.E.Ryu, S.J.Kim, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.51
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	183.941, 183.941, 119.976, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 24

The structure of Crystal Structure of Ed-EYA2 Complexed with ALF3 also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Magnesium	(Mg)	4 atoms

The binding sites of Aluminium atom in the Crystal Structure of Ed-EYA2 Complexed with ALF3 (pdb code 3hb1). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 4 binding sites of Aluminium where determined in the Crystal Structure of Ed-EYA2 Complexed with ALF3, PDB code: 3hb1:
Jump to Aluminium binding site number: 1; 2; 3; 4;

Aluminium binding site 1 out of 4 in the Crystal Structure of Ed-EYA2 Complexed with ALF3


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Crystal Structure of Ed-EYA2 Complexed with ALF3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Al801 b:41.8 occ:1.00 AL A:AF3801 0.0 41.8 1.0 F2 A:AF3801 1.7 44.5 1.0 F1 A:AF3801 1.7 45.1 1.0 F3 A:AF3801 1.7 42.3 1.0 OD1 A:ASP274 2.0 37.4 1.0 CG A:ASP274 3.1 33.8 1.0 OD2 A:ASP274 3.5 34.0 1.0 OD1 A:ASP276 3.6 32.6 1.0 MG A:MG701 3.6 26.8 1.0 O A:HOH75 3.7 35.7 1.0 OG1 A:THR448 3.8 41.3 1.0 OG1 A:THR447 3.9 31.0 1.0 NZ A:LYS480 3.9 31.8 1.0 N A:LEU275 4.0 26.5 1.0 N A:ASP276 4.0 30.1 1.0 N A:THR448 4.1 35.1 1.0 CB A:ASP276 4.4 30.5 1.0 CB A:ASP274 4.4 29.7 1.0 CA A:THR447 4.4 32.0 1.0 OE2 A:GLU506 4.4 44.1 1.0 CG A:ASP276 4.5 31.0 1.0 CB A:THR447 4.6 30.5 1.0 O A:ASP276 4.7 31.8 1.0 CA A:ASP276 4.7 30.6 1.0 O A:HOH143 4.7 36.7 1.0 CE A:LYS480 4.7 33.2 1.0 CA A:ASP274 4.8 28.1 1.0 CA A:LEU275 4.8 27.2 1.0 C A:THR447 4.8 33.8 1.0 CB A:THR448 4.8 38.1 1.0 C A:ASP274 4.9 26.9 1.0 C A:LEU275 4.9 28.4 1.0 O A:VAL446 4.9 29.0 1.0 CB A:LEU275 4.9 27.2 1.0

Aluminium binding site 2 out of 4 in the Crystal Structure of Ed-EYA2 Complexed with ALF3


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Crystal Structure of Ed-EYA2 Complexed with ALF3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Al802 b:46.5 occ:1.00 AL B:AF3802 0.0 46.5 1.0 F2 B:AF3802 1.7 50.2 1.0 F1 B:AF3802 1.7 46.0 1.0 F3 B:AF3802 1.7 44.9 1.0 OD1 B:ASP274 2.0 43.9 1.0 CG B:ASP274 3.0 40.9 1.0 OD2 B:ASP274 3.4 39.4 1.0 MG B:MG702 3.6 35.2 1.0 OD1 B:ASP276 3.6 44.3 1.0 N B:ASP276 3.8 35.3 1.0 OG1 B:THR447 3.9 40.0 1.0 CB B:ASP276 3.9 40.8 1.0 N B:THR448 4.0 43.8 1.0 N B:LEU275 4.1 35.4 1.0 CG B:ASP276 4.2 44.6 1.0 NZ B:LYS480 4.2 51.5 1.0 O B:ASP276 4.3 35.2 1.0 OG1 B:THR448 4.3 46.7 1.0 CA B:ASP276 4.3 36.3 1.0 CA B:THR447 4.4 39.6 1.0 CB B:ASP274 4.4 38.1 1.0 CB B:THR448 4.4 46.1 1.0 CB B:THR447 4.5 39.5 1.0 CE B:LYS480 4.6 51.4 1.0 C B:LEU275 4.6 34.7 1.0 OE2 B:GLU506 4.7 50.3 1.0 C B:THR447 4.8 41.6 1.0 CA B:LEU275 4.8 34.3 1.0 C B:ASP276 4.8 35.5 1.0 O B:HOH137 4.8 37.4 1.0 CA B:ASP274 4.8 36.4 1.0 C B:ASP274 4.9 36.8 1.0 CA B:THR448 4.9 45.6 1.0 O B:VAL446 4.9 36.5 1.0 CB B:LEU275 4.9 33.9 1.0

Aluminium binding site 3 out of 4 in the Crystal Structure of Ed-EYA2 Complexed with ALF3


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 3 of Crystal Structure of Ed-EYA2 Complexed with ALF3 within 5.0Å range: probe atom residue distance (Å) B Occ C:Al803 b:48.0 occ:1.00 AL C:AF3803 0.0 48.0 1.0 F3 C:AF3803 1.7 49.2 1.0 F2 C:AF3803 1.7 44.7 1.0 F1 C:AF3803 1.7 49.9 1.0 OD1 C:ASP274 2.0 43.5 1.0 CG C:ASP274 3.1 39.0 1.0 MG C:MG703 3.3 24.1 1.0 OD2 C:ASP274 3.4 39.2 1.0 NZ C:LYS480 3.7 46.4 1.0 OD1 C:ASP276 3.9 43.3 1.0 OG1 C:THR448 3.9 51.1 1.0 N C:ASP276 4.0 37.2 1.0 N C:LEU275 4.2 35.8 1.0 O C:HOH142 4.2 42.5 1.0 CB C:ASP276 4.2 40.7 1.0 OG1 C:THR447 4.2 40.8 1.0 N C:THR448 4.3 45.5 1.0 OE2 C:GLU506 4.4 53.8 1.0 O C:ASP276 4.4 37.7 1.0 CB C:ASP274 4.4 35.7 1.0 CG2 C:THR448 4.5 49.0 1.0 CG C:ASP276 4.5 42.6 1.0 CA C:ASP276 4.6 38.1 1.0 CE C:LYS480 4.6 46.7 1.0 CB C:THR448 4.7 48.1 1.0 CA C:THR447 4.8 41.4 1.0 C C:LEU275 4.9 36.7 1.0 CA C:ASP274 4.9 35.5 1.0 CB C:THR447 4.9 40.3 1.0 O C:HOH138 4.9 45.8 1.0 CA C:LEU275 4.9 35.0 1.0 C C:ASP276 5.0 37.2 1.0

Aluminium binding site 4 out of 4 in the Crystal Structure of Ed-EYA2 Complexed with ALF3


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 4 of Crystal Structure of Ed-EYA2 Complexed with ALF3 within 5.0Å range: probe atom residue distance (Å) B Occ D:Al804 b:47.6 occ:1.00 AL D:AF3804 0.0 47.6 1.0 F1 D:AF3804 1.7 48.6 1.0 F3 D:AF3804 1.7 50.2 1.0 F2 D:AF3804 1.7 44.0 1.0 OD1 D:ASP274 2.0 44.8 1.0 CG D:ASP274 3.1 41.3 1.0 MG D:MG704 3.3 32.5 1.0 OD2 D:ASP274 3.5 42.2 1.0 N D:ASP276 3.8 35.1 1.0 OD1 D:ASP276 3.8 46.8 1.0 NZ D:LYS480 3.8 36.4 1.0 OG1 D:THR448 3.8 43.1 1.0 OG1 D:THR447 3.9 34.2 1.0 CB D:ASP276 4.0 39.4 1.0 N D:LEU275 4.0 32.7 1.0 N D:THR448 4.2 39.6 1.0 CA D:ASP276 4.3 36.4 1.0 CG D:ASP276 4.3 44.0 1.0 O D:ASP276 4.4 34.9 1.0 CB D:ASP274 4.4 34.7 1.0 OE2 D:GLU506 4.5 47.5 1.0 O D:HOH139 4.5 25.4 1.0 CA D:THR447 4.5 36.0 1.0 CE D:LYS480 4.6 37.8 1.0 CB D:THR447 4.6 35.1 1.0 C D:LEU275 4.6 33.0 1.0 CA D:LEU275 4.7 31.7 1.0 CB D:LEU275 4.8 30.8 1.0 CA D:ASP274 4.8 33.0 1.0 C D:ASP274 4.8 33.5 1.0 C D:ASP276 4.8 36.1 1.0 CB D:THR448 4.9 40.5 1.0 C D:THR447 5.0 38.1 1.0

S.K.Jung, D.G.Jeong, S.J.Chung, J.H.Kim, B.C.Park, N.K.Tonks, S.E.Ryu, S.J.Kim. Crystal Structure of Ed-EYA2: Insight Into Dual Roles As A Protein Tyrosine Phosphatase and A Transcription Factor Faseb J. V. 24 560 2010.
ISSN: ISSN 0892-6638
PubMed: 19858093
DOI: 10.1096/FJ.09-143891