Aluminium in PDB 5do9: Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q

The structure of Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q, PDB code: 5do9 was solved by V.G.Taylor, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	173.946, 95.881, 112.898, 90.00, 94.31, 90.00
R / Rfree (%)	17.8 / 22.6

The structure of Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Magnesium	(Mg)	3 atoms

The binding sites of Aluminium atom in the Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q (pdb code 5do9). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 3 binding sites of Aluminium where determined in the Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q, PDB code: 5do9:
Jump to Aluminium binding site number: 1; 2; 3;

Aluminium binding site 1 out of 3 in the Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q within 5.0Å range: probe atom residue distance (Å) B Occ A:Al402 b:28.1 occ:1.00 AL A:ALF402 0.0 28.1 1.0 F1 A:ALF402 1.7 28.1 1.0 F3 A:ALF402 1.8 27.7 1.0 F4 A:ALF402 1.8 27.0 1.0 F2 A:ALF402 1.8 26.5 1.0 O1B A:GDP401 1.9 23.8 1.0 O A:HOH525 2.0 30.1 1.0 PB A:GDP401 3.2 24.1 1.0 MG A:MG403 3.4 25.2 1.0 NH1 A:ARG183 3.7 33.0 1.0 O2B A:GDP401 3.7 23.5 1.0 N A:GLU49 3.9 33.0 1.0 N A:THR186 3.9 26.8 1.0 O A:HOH512 3.9 23.6 1.0 NH2 A:ARG183 3.9 30.1 1.0 NZ A:LYS52 4.1 26.1 1.0 O3B A:GDP401 4.1 22.6 1.0 N A:GLY208 4.2 27.8 1.0 OE1 A:GLN209 4.2 24.1 1.0 O3A A:GDP401 4.2 24.3 1.0 O A:HOH509 4.2 23.1 1.0 NE2 A:GLN209 4.2 24.2 1.0 CA A:GLY48 4.2 30.4 1.0 CB A:THR186 4.3 25.8 1.0 CZ A:ARG183 4.3 31.4 1.0 O A:THR186 4.4 26.4 1.0 OG1 A:THR186 4.4 25.2 1.0 CA A:THR186 4.6 26.6 1.0 C A:GLY48 4.6 30.7 1.0 CD A:GLN209 4.6 25.4 1.0 CA A:PRO185 4.7 27.2 1.0 CA A:GLY207 4.8 26.3 1.0 C A:PRO185 4.8 26.6 1.0 CA A:GLU49 4.8 32.3 1.0 CE A:LYS52 4.9 26.9 1.0 CA A:GLY208 4.9 27.0 1.0 C A:THR186 5.0 26.4 1.0 C A:GLY207 5.0 26.9 1.0

Aluminium binding site 2 out of 3 in the Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q within 5.0Å range: probe atom residue distance (Å) B Occ C:Al402 b:25.7 occ:1.00 AL C:ALF402 0.0 25.7 1.0 F1 C:ALF402 1.8 27.7 1.0 F3 C:ALF402 1.8 24.3 1.0 F4 C:ALF402 1.8 24.9 1.0 F2 C:ALF402 1.8 24.3 1.0 O3B C:GDP401 1.9 22.4 1.0 O C:HOH517 2.0 26.3 1.0 MG C:MG403 3.2 25.8 1.0 PB C:GDP401 3.2 23.8 1.0 NH1 C:ARG183 3.8 32.1 1.0 O C:HOH502 3.8 27.4 1.0 O2B C:GDP401 3.9 22.0 1.0 NH2 C:ARG183 3.9 31.2 1.0 N C:GLU49 3.9 36.9 1.0 N C:THR186 3.9 30.8 1.0 NZ C:LYS52 4.1 23.5 1.0 NE2 C:GLN209 4.1 27.1 1.0 OE1 C:GLN209 4.1 25.5 1.0 OG1 C:THR186 4.1 30.2 1.0 N C:GLY208 4.1 29.1 1.0 O1B C:GDP401 4.2 22.7 1.0 CB C:THR186 4.3 29.2 1.0 CA C:GLY48 4.3 32.2 1.0 O C:HOH505 4.3 24.0 1.0 CZ C:ARG183 4.3 32.2 1.0 O3A C:GDP401 4.4 24.9 1.0 O C:THR186 4.5 29.1 1.0 CD C:GLN209 4.6 26.6 1.0 CA C:THR186 4.6 29.2 1.0 C C:GLY48 4.6 32.5 1.0 CA C:PRO185 4.7 33.9 1.0 CA C:GLY207 4.7 27.3 1.0 CE C:LYS52 4.8 23.2 1.0 C C:PRO185 4.8 32.0 1.0 CA C:GLU49 4.8 39.0 1.0 O C:VAL206 4.9 25.9 1.0 CA C:GLY208 4.9 28.9 1.0 C C:GLY207 4.9 28.8 1.0 O2A C:GDP401 5.0 25.8 1.0

Aluminium binding site 3 out of 3 in the Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 3 of Structure of Regulator of G Protein Signaling 8 (RGS8) in Complex with ALF4-Activated Galpha-Q within 5.0Å range: probe atom residue distance (Å) B Occ E:Al402 b:28.5 occ:1.00 AL E:ALF402 0.0 28.5 1.0 O E:HOH555 1.8 22.0 1.0 F1 E:ALF402 1.8 27.3 1.0 F3 E:ALF402 1.8 26.9 1.0 O1B E:GDP401 1.8 18.9 1.0 F4 E:ALF402 1.8 25.5 1.0 F2 E:ALF402 1.8 27.0 1.0 PB E:GDP401 3.1 20.3 1.0 MG E:MG403 3.3 22.9 1.0 O E:HOH512 3.6 21.8 1.0 O2B E:GDP401 3.7 20.2 1.0 N E:GLU49 3.9 28.5 1.0 N E:THR186 3.9 25.5 1.0 O3B E:GDP401 4.0 18.6 1.0 NH1 E:ARG183 4.0 29.1 1.0 NZ E:LYS52 4.0 24.1 1.0 O E:HOH504 4.1 28.6 1.0 NH2 E:ARG183 4.1 26.0 1.0 OG1 E:THR186 4.1 24.4 1.0 CB E:THR186 4.1 25.5 1.0 NE2 E:GLN209 4.2 26.3 1.0 O3A E:GDP401 4.2 21.9 1.0 N E:GLY208 4.2 27.3 1.0 OE1 E:GLN209 4.3 26.4 1.0 CA E:GLY48 4.4 26.2 1.0 O E:THR186 4.4 27.2 1.0 CA E:THR186 4.5 26.1 1.0 CZ E:ARG183 4.6 27.5 1.0 C E:GLY48 4.7 26.1 1.0 CD E:GLN209 4.7 26.5 1.0 CA E:GLY207 4.7 26.3 1.0 CE E:LYS52 4.7 23.2 1.0 O E:VAL206 4.7 25.1 1.0 CA E:GLU49 4.8 31.2 1.0 CA E:PRO185 4.8 26.5 1.0 C E:PRO185 4.8 25.8 1.0 C E:GLY207 4.9 26.5 1.0 CA E:GLY208 4.9 25.9 1.0 C E:THR186 5.0 26.9 1.0

V.G.Taylor, P.A.Bommarito, J.J.Tesmer. Structure of the Regulator of G Protein Signaling 8 (RGS8)-G Alpha Q Complex: Molecular Basis For G Alpha Selectivity. J.Biol.Chem. V. 291 5138 2016.
ISSN: ESSN 1083-351X
PubMed: 26755720
DOI: 10.1074/JBC.M115.712075