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Aluminium in PDB 5lih: Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain

Enzymatic activity of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain

All present enzymatic activity of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain:
2.7.11.13;

Protein crystallography data

The structure of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain, PDB code: 5lih was solved by E.V.Soriano, A.G.Purkiss, N.Q.Mcdonald, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 67.28 / 3.25
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.980, 84.230, 111.830, 90.00, 90.00, 90.00
R / Rfree (%) 25.7 / 28.4

Other elements in 5lih:

The structure of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain also contains other interesting chemical elements:

Fluorine (F) 12 atoms
Manganese (Mn) 5 atoms

Aluminium Binding Sites:

The binding sites of Aluminium atom in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain (pdb code 5lih). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 4 binding sites of Aluminium where determined in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain, PDB code: 5lih:
Jump to Aluminium binding site number: 1; 2; 3; 4;

Aluminium binding site 1 out of 4 in 5lih

Go back to Aluminium Binding Sites List in 5lih
Aluminium binding site 1 out of 4 in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Al602

b:37.9
occ:1.00
 AL A:AF3602 0.0 37.9 1.0
F3 A:AF3602 1.8 37.9 1.0
F2 A:AF3602 1.8 37.9 1.0
F1 A:AF3602 1.8 37.9 1.0
O A:TYR419 3.4 29.4 1.0
O A:ARG377 3.9 31.5 1.0
C A:ARG377 3.9 31.8 1.0
O A:VAL434 4.0 31.7 1.0
C A:TYR419 4.1 29.4 1.0
CA A:ARG377 4.2 33.3 1.0
CA A:ILE420 4.2 31.1 1.0
CB A:ALA438 4.3 27.8 1.0
N A:ASP378 4.5 30.6 1.0
N A:ILE420 4.5 30.8 1.0
CB A:TYR419 4.6 29.8 1.0
N A:ALA421 4.6 26.0 1.0
CB A:VAL434 4.7 35.1 1.0
CA A:GLY415 4.7 34.2 1.0
CD1 A:ILE424 4.8 35.2 1.0
O A:CYS414 4.8 35.9 1.0
C A:VAL434 4.8 33.1 1.0
CA A:ASP378 4.9 30.1 1.0
C A:ILE420 4.9 31.6 1.0
CB A:ARG377 4.9 34.8 1.0
CG2 A:VAL434 5.0 35.9 1.0

Aluminium binding site 2 out of 4 in 5lih

Go back to Aluminium Binding Sites List in 5lih
Aluminium binding site 2 out of 4 in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Al605

b:54.5
occ:1.00
 AL A:AF3605 0.0 54.5 1.0
F3 A:AF3605 1.8 34.8 1.0
F1 A:AF3605 1.8 22.1 1.0
F2 A:AF3605 1.8 63.9 1.0
O1B A:ADP601 2.4 40.8 1.0
OD2 A:ASP396 3.0 34.3 1.0
OG F:SER11 3.2 43.9 1.0
PB A:ADP601 3.4 45.0 1.0
O2B A:ADP601 3.4 43.8 1.0
MN A:MN603 3.6 31.8 1.0
MN A:MN604 3.6 38.7 1.0
CB F:SER11 3.8 43.2 1.0
N F:SER11 3.8 41.5 1.0
OG A:SER264 4.0 37.6 1.0
O1A A:ADP601 4.1 33.5 1.0
CE A:LYS380 4.1 31.4 1.0
CG A:ASP396 4.1 34.4 1.0
OD2 A:ASP378 4.2 30.9 1.0
O3B A:ADP601 4.3 58.6 1.0
CA F:SER11 4.4 42.2 1.0
N A:SER264 4.5 36.9 1.0
OD1 A:ASP396 4.6 34.5 1.0
O3A A:ADP601 4.6 36.4 1.0
OD1 A:ASN383 4.7 31.2 0.5
OD1 A:ASN383 4.7 31.2 0.5
CA F:GLY10 4.8 40.5 1.0
C F:GLY10 4.8 40.8 1.0
CA A:GLY263 4.9 36.4 1.0

Aluminium binding site 3 out of 4 in 5lih

Go back to Aluminium Binding Sites List in 5lih
Aluminium binding site 3 out of 4 in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 3 of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Al602

b:36.8
occ:1.00
 AL B:AF3602 0.0 36.8 1.0
F3 B:AF3602 1.8 36.8 1.0
F2 B:AF3602 1.8 36.8 1.0
F1 B:AF3602 1.8 36.8 1.0
C B:ARG377 3.6 42.0 1.0
O B:ARG377 3.7 43.1 1.0
O B:TYR419 3.7 40.7 1.0
O B:VAL434 3.9 35.1 1.0
CA B:ARG377 3.9 42.5 1.0
N B:ASP378 4.1 40.7 1.0
CB B:ALA438 4.2 31.6 1.0
C B:TYR419 4.3 41.0 1.0
CG B:ARG377 4.4 46.0 1.0
CA B:ASP378 4.5 40.5 1.0
CB B:TYR419 4.6 39.0 1.0
CB B:VAL434 4.6 37.3 1.0
C B:VAL434 4.7 35.1 1.0
CA B:ILE420 4.7 37.5 1.0
N B:LEU379 4.7 35.6 1.0
CB B:ARG377 4.8 44.2 1.0
N B:ILE420 4.8 36.6 1.0
CA B:GLY415 4.8 44.9 1.0
CG2 B:VAL434 4.8 36.9 1.0
N B:ARG377 5.0 41.3 1.0

Aluminium binding site 4 out of 4 in 5lih

Go back to Aluminium Binding Sites List in 5lih
Aluminium binding site 4 out of 4 in the Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 4 of Structure of A Peptide-Substrate Bound to Pkciota Core Kinase Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Al605

b:59.4
occ:1.00
 AL B:AF3605 0.0 59.4 1.0
F1 B:AF3605 1.8 26.9 1.0
F2 B:AF3605 1.8 68.7 1.0
F3 B:AF3605 1.8 39.6 1.0
O1B B:ADP601 2.4 44.1 1.0
MN B:MN604 2.9 40.7 1.0
OG G:SER11 3.1 48.4 1.0
PB B:ADP601 3.5 38.5 1.0
CB G:SER11 3.5 46.9 1.0
OD2 B:ASP396 3.6 41.9 1.0
N G:SER11 3.6 44.5 1.0
MN B:MN603 3.6 50.6 1.0
N B:SER264 3.9 43.9 1.0
O3B B:ADP601 4.0 46.1 1.0
O2B B:ADP601 4.1 38.3 1.0
CA G:SER11 4.2 45.3 1.0
CB B:SER264 4.3 46.3 1.0
CE B:LYS380 4.4 39.0 1.0
O1A B:ADP601 4.5 46.0 1.0
OD2 B:ASP378 4.5 41.2 1.0
CA B:GLY263 4.6 42.2 1.0
C G:GLY10 4.6 50.4 1.0
CG B:ASP396 4.7 41.8 1.0
CA B:SER264 4.7 45.5 1.0
CA G:GLY10 4.7 50.1 1.0
C B:GLY263 4.7 43.8 1.0
O3A B:ADP601 4.8 45.9 1.0
O B:HOH705 4.9 37.6 1.0

Reference:

E.V.Soriano, M.E.Ivanova, G.Fletcher, P.Riou, P.P.Knowles, K.Barnouin, A.Purkiss, B.Kostelecky, P.Saiu, M.Linch, A.Elbediwy, S.Kjr, N.O'reilly, A.P.Snijders, P.J.Parker, B.J.Thompson, N.Q.Mcdonald. Apkc Inhibition By PAR3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev.Cell V. 38 384 2016.
ISSN: ISSN 1534-5807
PubMed: 27554858
DOI: 10.1016/J.DEVCEL.2016.07.018
Page generated: Wed Jul 10 09:50:37 2024

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