Aluminium in PDB 7jl2: Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer)

All present enzymatic activity of Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer):
3.6.4.13;

The structure of Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer) also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Magnesium	(Mg)	3 atoms
Zinc	(Zn)	3 atoms

The binding sites of Aluminium atom in the Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer) (pdb code 7jl2). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 3 binding sites of Aluminium where determined in the Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer), PDB code: 7jl2:
Jump to Aluminium binding site number: 1; 2; 3;

Aluminium binding site 1 out of 3 in the Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer) within 5.0Å range: probe atom residue distance (Å) B Occ A:Al1103 b:73.5 occ:1.00 AL A:ALF1103 0.0 73.5 1.0 F1 A:ALF1103 1.8 73.5 1.0 F4 A:ALF1103 1.8 73.5 1.0 F2 A:ALF1103 1.8 73.5 1.0 F3 A:ALF1103 1.8 73.5 1.0 O2B A:ADP1102 2.5 73.6 1.0 MG A:MG1104 2.5 59.3 1.0 O1B A:ADP1102 2.6 73.6 1.0 PB A:ADP1102 3.0 73.6 1.0 NZ A:LYS335 3.6 95.0 1.0 O3A A:ADP1102 4.1 73.6 1.0 CE A:LYS335 4.1 95.0 1.0 O3B A:ADP1102 4.2 73.6 1.0 NH2 A:ARG824 4.4 95.0 1.0 OE1 A:GLN818 4.6 95.0 1.0 NH2 A:ARG822 4.6 95.0 1.0 CA A:GLY795 5.0 61.3 1.0

Aluminium binding site 2 out of 3 in the Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer) within 5.0Å range: probe atom residue distance (Å) B Occ C:Al1103 b:88.8 occ:1.00 AL C:ALF1103 0.0 88.8 1.0 F4 C:ALF1103 1.8 88.8 1.0 F3 C:ALF1103 1.8 88.8 1.0 F2 C:ALF1103 1.8 88.8 1.0 F1 C:ALF1103 1.8 88.8 1.0 O2B C:ADP1102 2.5 85.8 1.0 MG C:MG1104 2.5 87.2 1.0 O1B C:ADP1102 2.6 85.8 1.0 PB C:ADP1102 3.0 85.8 1.0 NZ C:LYS335 3.6 95.0 1.0 O3A C:ADP1102 4.1 85.8 1.0 CE C:LYS335 4.1 95.0 1.0 O3B C:ADP1102 4.2 85.8 1.0 NH2 C:ARG824 4.4 95.0 1.0 OE1 C:GLN818 4.6 95.0 1.0 NH2 C:ARG822 4.6 95.0 1.0 CA C:GLY795 5.0 70.9 1.0

Aluminium binding site 3 out of 3 in the Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 3 of Cryo-Em Structure of MDA5-Dsrna Filament in Complex with TRIM65 Pspry Domain (Trimer) within 5.0Å range: probe atom residue distance (Å) B Occ E:Al1103 b:75.0 occ:1.00 AL E:ALF1103 0.0 75.0 1.0 F3 E:ALF1103 1.8 75.0 1.0 F4 E:ALF1103 1.8 75.0 1.0 F2 E:ALF1103 1.8 75.0 1.0 F1 E:ALF1103 1.8 75.0 1.0 O2B E:ADP1102 2.5 76.2 1.0 MG E:MG1104 2.5 66.8 1.0 O1B E:ADP1102 2.6 76.2 1.0 PB E:ADP1102 3.0 76.2 1.0 NZ E:LYS335 3.6 95.0 1.0 O3A E:ADP1102 4.1 76.2 1.0 CE E:LYS335 4.1 95.0 1.0 O3B E:ADP1102 4.2 76.2 1.0 NH2 E:ARG824 4.4 95.0 1.0 OE1 E:GLN818 4.6 95.0 1.0 NH2 E:ARG822 4.6 95.0 1.0 CA E:GLY795 5.0 61.8 1.0

K.Kato, S.Ahmad, Z.Zhu, J.M.Young, X.Mu, S.Park, H.S.Malik, S.Hur. Structural Analysis of Rig-I-Like Receptors Reveals Ancient Rules of Engagement Between Diverse Rna Helicases and Trim Ubiquitin Ligases Mol.Cell 2020.
ISSN: ISSN 1097-2765