Aluminium in PDB 7rdx: Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class:
2.7.7.48; 3.6.4.12; 3.6.4.13;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Magnesium	(Mg)	3 atoms
Zinc	(Zn)	8 atoms

The binding sites of Aluminium atom in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class (pdb code 7rdx). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 2 binding sites of Aluminium where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class, PDB code: 7rdx:
Jump to Aluminium binding site number: 1; 2;

Aluminium binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class within 5.0Å range: probe atom residue distance (Å) B Occ E:Al706 b:115.0 occ:1.00 AL E:AF3706 0.0 115.0 1.0 F1 E:AF3706 1.8 115.0 1.0 F2 E:AF3706 1.8 115.0 1.0 F3 E:AF3706 1.8 115.0 1.0 MG E:MG705 2.0 108.5 1.0 O3B E:ADP704 2.3 115.4 1.0 OE2 E:GLU375 3.1 96.7 1.0 HA2 E:GLY538 3.3 123.4 1.0 PB E:ADP704 3.6 115.4 1.0 OG E:SER289 3.6 104.9 1.0 HE2 E:LYS288 3.8 103.1 1.0 O2B E:ADP704 3.9 115.4 1.0 HE22 E:GLN404 3.9 113.5 1.0 HH12 E:ARG443 3.9 130.5 1.0 H E:GLY285 3.9 119.3 1.0 HZ1 E:LYS288 4.1 103.1 1.0 O1A E:ADP704 4.1 115.4 1.0 HH22 E:ARG567 4.1 133.8 1.0 CD E:GLU375 4.2 96.7 1.0 CA E:GLY538 4.2 123.4 1.0 NH2 E:ARG567 4.2 133.8 1.0 H E:GLY538 4.3 123.4 1.0 HH21 E:ARG567 4.4 133.8 1.0 HH22 E:ARG443 4.4 130.5 1.0 HE3 E:LYS288 4.4 103.1 1.0 O3A E:ADP704 4.4 115.4 1.0 CE E:LYS288 4.5 103.1 1.0 HA E:PRO284 4.6 119.0 1.0 N E:GLY538 4.6 123.4 1.0 NH1 E:ARG443 4.6 130.5 1.0 CZ E:ARG567 4.7 133.8 1.0 O E:GLY538 4.7 123.4 1.0 O1B E:ADP704 4.7 115.4 1.0 NE2 E:GLN404 4.7 113.5 1.0 NZ E:LYS288 4.8 103.1 1.0 N E:GLY285 4.8 119.3 1.0 OE1 E:GLU375 4.8 96.7 1.0 HA3 E:GLY538 4.8 123.4 1.0 H E:SER289 4.9 104.9 1.0 PA E:ADP704 4.9 115.4 1.0 C E:GLY538 4.9 123.4 1.0 HG2 E:GLN537 4.9 121.3 1.0 HB2 E:LYS288 4.9 103.1 1.0 HH12 E:ARG567 4.9 133.8 1.0 CB E:SER289 4.9 104.9 1.0 OE1 E:GLN404 5.0 113.5 1.0 NH2 E:ARG443 5.0 130.5 1.0

Aluminium binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Open Class within 5.0Å range: probe atom residue distance (Å) B Occ F:Al1005 b:178.2 occ:1.00 AL F:AF31005 0.0 178.2 1.0 F1 F:AF31005 1.8 178.2 1.0 F3 F:AF31005 1.8 178.2 1.0 F2 F:AF31005 1.8 178.2 1.0 H F:GLY285 2.1 175.0 1.0 HZ1 F:LYS288 2.1 173.3 1.0 HA F:PRO284 2.6 175.7 1.0 O3B F:ADP1003 2.9 177.4 1.0 N F:GLY285 2.9 175.0 1.0 NZ F:LYS288 3.0 173.3 1.0 H F:THR286 3.2 175.6 1.0 PB F:ADP1003 3.2 177.4 1.0 O1B F:ADP1003 3.3 177.4 1.0 HE2 F:LYS288 3.4 173.3 1.0 O2B F:ADP1003 3.4 177.4 1.0 CA F:PRO284 3.4 175.7 1.0 HZ3 F:LYS288 3.5 173.3 1.0 HZ2 F:LYS288 3.5 173.3 1.0 C F:PRO284 3.6 175.7 1.0 CE F:LYS288 3.7 173.3 1.0 O F:PRO283 3.7 175.8 1.0 HA2 F:GLY285 3.8 175.0 1.0 CA F:GLY285 3.9 175.0 1.0 N F:THR286 3.9 175.6 1.0 HE3 F:LYS288 4.0 173.3 1.0 H F:GLY287 4.1 171.8 1.0 OG1 F:THR286 4.2 175.6 1.0 HB3 F:PRO284 4.3 175.7 1.0 N F:PRO284 4.3 175.7 1.0 C F:PRO283 4.4 175.8 1.0 C F:GLY285 4.4 175.0 1.0 CB F:PRO284 4.5 175.7 1.0 HG1 F:THR286 4.6 175.6 1.0 HG3 F:LYS288 4.6 173.3 1.0 HE21 F:GLN404 4.7 172.5 1.0 HA3 F:GLY285 4.7 175.0 1.0 O3A F:ADP1003 4.8 177.4 1.0 O F:PRO284 4.8 175.7 1.0 N F:GLY287 4.9 171.8 1.0 H F:LYS288 4.9 173.3 1.0 O F:GLY282 4.9 174.9 1.0

J.Chen, Q.Wang, B.Malone, E.C.Llewellyn, K.Maruthi, E.T.Eng, J.Perry, E.A.Campbell, D.E.Shaw, S.A.Darst. Ensemble Cryo-Electron Microscopy Reveals Conformational States of the Sars-Cov-2 Helicase Replication-Transcription Complex Biorxiv 2021.
DOI: 10.1101/2021.11.10.468168