Aluminium in PDB 7rdy: Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class:
2.7.7.48; 3.6.4.12; 3.6.4.13;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Magnesium	(Mg)	3 atoms
Zinc	(Zn)	8 atoms

The binding sites of Aluminium atom in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class (pdb code 7rdy). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 2 binding sites of Aluminium where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class, PDB code: 7rdy:
Jump to Aluminium binding site number: 1; 2;

Aluminium binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class within 5.0Å range: probe atom residue distance (Å) B Occ E:Al1005 b:102.9 occ:1.00 AL E:AF31005 0.0 102.9 1.0 F2 E:AF31005 1.8 102.9 1.0 F1 E:AF31005 1.8 102.9 1.0 F3 E:AF31005 1.8 102.9 1.0 O3B E:ADP1003 2.5 102.8 1.0 O1B E:ADP1003 3.0 102.8 1.0 PB E:ADP1003 3.2 102.8 1.0 NH2 E:ARG567 3.2 108.5 1.0 MG E:MG1004 3.4 99.9 1.0 OE1 E:GLN404 3.9 98.8 1.0 CA E:GLY538 3.9 105.8 1.0 NH1 E:ARG443 4.0 108.4 1.0 O2B E:ADP1003 4.0 102.8 1.0 N E:GLY285 4.1 102.6 1.0 N E:GLY538 4.2 105.8 1.0 CB E:PRO284 4.2 101.4 1.0 CA E:PRO284 4.3 101.4 1.0 CZ E:ARG567 4.3 108.5 1.0 NZ E:LYS288 4.3 95.0 1.0 OE2 E:GLU375 4.4 90.0 1.0 O3A E:ADP1003 4.5 102.8 1.0 CE E:LYS288 4.5 95.0 1.0 NH2 E:ARG443 4.6 108.4 1.0 C E:GLY538 4.7 105.8 1.0 C E:PRO284 4.7 101.4 1.0 CZ E:ARG443 4.7 108.4 1.0 CD E:GLN404 4.9 98.8 1.0 O E:GLY538 4.9 105.8 1.0 NE E:ARG567 5.0 108.5 1.0

Aluminium binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc - Engaged Class within 5.0Å range: probe atom residue distance (Å) B Occ F:Al1005 b:215.5 occ:1.00 AL F:AF31005 0.0 215.5 1.0 F1 F:AF31005 1.8 215.5 1.0 F3 F:AF31005 1.8 215.5 1.0 F2 F:AF31005 1.8 215.5 1.0 O3B F:ADP1003 2.7 215.1 1.0 N F:GLY285 3.5 216.2 1.0 CD F:LYS288 3.7 208.3 1.0 NZ F:LYS288 3.7 208.3 1.0 CA F:GLY285 3.7 216.2 1.0 CG F:LYS288 4.0 208.3 1.0 NH2 F:ARG443 4.1 228.1 1.0 PB F:ADP1003 4.1 215.1 1.0 NH1 F:ARG443 4.1 228.1 1.0 CE F:LYS288 4.2 208.3 1.0 C F:PRO284 4.6 215.3 1.0 CZ F:ARG443 4.6 228.1 1.0 O1A F:ADP1003 4.6 215.1 1.0 MG F:MG1004 4.6 208.9 1.0 NH2 F:ARG567 4.7 233.5 1.0 O2B F:ADP1003 4.8 215.1 1.0 O1B F:ADP1003 4.8 215.1 1.0 OE1 F:GLU375 4.9 196.8 1.0 CA F:PRO284 4.9 215.3 1.0 C F:GLY285 5.0 216.2 1.0

J.Chen, Q.Wang, B.Malone, E.Llewellyn, Y.Pechersky, K.Maruthi, E.T.Eng, J.K.Perry, E.A.Campbell, D.E.Shaw, S.A.Darst. Ensemble Cryo-Electron Microscopy Reveals Conformational States of the NSP13 Helicase in the Sars-Cov-2 Helicase Replication-Transcription Complex Biorxiv 2021.
DOI: 10.1101/2021.11.10.468168