Aluminium in PDB 7re1: Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite)

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite):
2.7.7.48; 3.6.4.12; 3.6.4.13;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite) also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Magnesium	(Mg)	3 atoms
Zinc	(Zn)	8 atoms

The binding sites of Aluminium atom in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite) (pdb code 7re1). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 2 binding sites of Aluminium where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite), PDB code: 7re1:
Jump to Aluminium binding site number: 1; 2;

Aluminium binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ E:Al706 b:86.8 occ:1.00 AL E:AF3706 0.0 86.8 1.0 F2 E:AF3706 1.8 86.8 1.0 F3 E:AF3706 1.8 86.8 1.0 F1 E:AF3706 1.8 86.8 1.0 O3B E:ADP704 2.5 84.8 1.0 O1B E:ADP704 2.9 84.8 1.0 PB E:ADP704 3.1 84.8 1.0 MG E:MG705 3.2 86.2 1.0 OE2 E:GLU375 3.4 87.3 1.0 NH2 E:ARG567 3.7 88.5 1.0 NE2 E:GLN404 4.0 88.5 1.0 O2B E:ADP704 4.0 84.8 1.0 CA E:GLY538 4.1 92.0 1.0 N E:GLY538 4.2 92.0 1.0 CB E:PRO284 4.3 85.1 1.0 CA E:PRO284 4.3 85.1 1.0 N E:GLY285 4.4 84.9 1.0 NH1 E:ARG443 4.4 85.4 1.0 NZ E:LYS288 4.4 83.4 1.0 CD E:GLU375 4.4 87.3 1.0 O3A E:ADP704 4.5 84.8 1.0 CZ E:ARG567 4.6 88.5 1.0 CE E:LYS288 4.7 83.4 1.0 OE1 E:GLU375 4.8 87.3 1.0 C E:PRO284 4.9 85.1 1.0 NH2 E:ARG443 4.9 85.4 1.0 C E:GLY538 5.0 92.0 1.0

Aluminium binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ F:Al1005 b:106.5 occ:1.00 AL F:AF31005 0.0 106.5 1.0 F2 F:AF31005 1.8 106.5 1.0 F3 F:AF31005 1.8 106.5 1.0 F1 F:AF31005 1.8 106.5 1.0 O3B F:ADP1003 2.9 108.4 1.0 NZ F:LYS288 3.1 102.9 1.0 O2B F:ADP1003 3.2 108.4 1.0 PB F:ADP1003 3.3 108.4 1.0 N F:GLY285 3.6 107.9 1.0 MG F:MG1004 3.7 106.9 1.0 O1B F:ADP1003 3.8 108.4 1.0 CA F:PRO284 4.0 107.6 1.0 CE F:LYS288 4.1 102.9 1.0 O F:GLY282 4.2 102.3 1.0 O F:PRO283 4.3 105.9 1.0 C F:PRO284 4.4 107.6 1.0 CA F:GLY285 4.5 107.9 1.0 NH2 F:ARG567 4.5 114.5 1.0 NE2 F:GLN404 4.7 105.0 1.0 N F:THR286 4.8 106.9 1.0 C F:PRO283 4.8 105.9 1.0 N F:PRO284 4.8 107.6 1.0 O3A F:ADP1003 4.9 108.4 1.0

J.Chen, Q.Wang, B.Malone, E.Llewellyn, Y.Pechersky, K.Maruthi, E.T.Eng, J.K.Perry, E.A.Campbell, D.E.Shaw, S.A.Darst. Ensemble Cryo-Electron Microscopy Reveals Conformational States of the NSP13 Helicase in the Sars-Cov-2 Helicase Replication-Transcription Complex Biorxiv 2021.
DOI: 10.1101/2021.11.10.468168