Aluminium in PDB 8ox5: Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation

All present enzymatic activity of Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation:
7.6.2.1;

The structure of Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Magnesium	(Mg)	1 atom

The binding sites of Aluminium atom in the Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation (pdb code 8ox5). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total only one binding site of Aluminium was determined in the Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation, PDB code: 8ox5:

Aluminium binding site 1 out of 1 in the Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Cryo-Em Structure of ATP8B1-CDC50A in E1P-Adp Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Al1202 b:43.9 occ:1.00 AL A:ALF1202 0.0 43.9 1.0 F1 A:ALF1202 1.8 43.9 1.0 F4 A:ALF1202 1.8 43.9 1.0 F3 A:ALF1202 1.8 43.9 1.0 F2 A:ALF1202 1.8 43.9 1.0 OD1 A:ASP454 1.8 33.1 1.0 O1B A:ADP1201 2.1 54.1 1.0 OD2 A:ASP454 2.4 33.1 1.0 CG A:ASP454 2.5 33.1 1.0 MG A:MG1203 2.8 34.1 1.0 O1A A:ADP1201 3.1 54.1 1.0 ND2 A:ASN896 3.3 36.3 1.0 PB A:ADP1201 3.4 54.1 1.0 O A:ASP454 3.7 33.1 1.0 O2B A:ADP1201 3.8 54.1 1.0 CB A:ASP454 3.9 33.1 1.0 PA A:ADP1201 4.2 54.1 1.0 OD2 A:ASP897 4.3 30.3 1.0 O3A A:ADP1201 4.3 54.1 1.0 CG A:ASN896 4.3 36.3 1.0 OG1 A:THR732 4.3 42.7 1.0 CB A:THR456 4.4 36.7 1.0 C A:ASP454 4.4 33.1 1.0 O3B A:ADP1201 4.5 54.1 1.0 OD1 A:ASN896 4.5 36.3 1.0 CA A:ASP454 4.5 33.1 1.0 O A:THR456 4.6 36.7 1.0 OE2 A:GLU914 4.6 35.5 1.0 NZ A:LYS873 4.6 35.4 1.0 N A:THR456 4.7 36.7 1.0 O2A A:ADP1201 4.7 54.1 1.0 OG1 A:THR456 4.7 36.7 1.0 OD1 A:ASP893 4.8 28.5 1.0 CA A:THR456 5.0 36.7 1.0

T.Dieudonne, F.Kummerer, M.J.Laursen, C.Stock, R.K.Flygaard, S.Khalid, G.Lenoir, J.A.Lyons, K.Lindorff-Larsen, P.Nissen. Activation and Substrate Specificity of the Human P4-Atpase ATP8B1. Nat Commun V. 14 7492 2023.
ISSN: ESSN 2041-1723
PubMed: 37980352
DOI: 10.1038/S41467-023-42828-9