Aluminium in PDB 6b9f: Human ATL1 Mutant - F151S Bound to GDPALF4-

The structure of Human ATL1 Mutant - F151S Bound to GDPALF4-, PDB code: 6b9f was solved by J.P.O'donnell, H.Sondermann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.68 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.613, 115.721, 184.300, 90.00, 90.00, 90.00
R / Rfree (%)	17.8 / 22.2

The structure of Human ATL1 Mutant - F151S Bound to GDPALF4- also contains other interesting chemical elements:

Fluorine	(F)	8 atoms
Magnesium	(Mg)	2 atoms

The binding sites of Aluminium atom in the Human ATL1 Mutant - F151S Bound to GDPALF4- (pdb code 6b9f). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 2 binding sites of Aluminium where determined in the Human ATL1 Mutant - F151S Bound to GDPALF4-, PDB code: 6b9f:
Jump to Aluminium binding site number: 1; 2;

Aluminium binding site 1 out of 2 in the Human ATL1 Mutant - F151S Bound to GDPALF4-


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Human ATL1 Mutant - F151S Bound to GDPALF4- within 5.0Å range: probe atom residue distance (Å) B Occ A:Al507 b:18.8 occ:1.00 AL A:ALF507 0.0 18.8 1.0 F3 A:ALF507 1.8 17.8 1.0 F4 A:ALF507 1.8 20.9 1.0 F2 A:ALF507 1.8 16.2 1.0 F1 A:ALF507 1.8 22.4 1.0 O3B A:GDP506 2.1 17.8 1.0 O A:HOH658 2.1 17.9 1.0 PB A:GDP506 3.3 17.5 1.0 MG A:MG505 3.5 19.2 1.0 O1B A:GDP506 3.8 13.1 1.0 N A:ARG77 3.9 19.9 1.0 NH2 A:ARG77 3.9 17.4 1.0 N A:THR120 4.0 22.6 1.0 N A:GLU119 4.0 17.9 1.0 O2B A:GDP506 4.0 17.4 1.0 NE A:ARG77 4.1 17.4 1.0 NZ A:LYS80 4.1 15.3 1.0 O A:HOH677 4.1 22.8 1.0 O A:HOH687 4.2 16.3 1.0 N A:GLY149 4.2 26.1 1.0 CB A:PHE76 4.3 16.4 1.0 OG1 A:THR120 4.3 15.9 1.0 CB A:THR120 4.3 18.1 1.0 O A:HOH663 4.4 20.2 1.0 CA A:PHE76 4.4 16.3 1.0 O A:THR120 4.4 19.8 1.0 CZ A:ARG77 4.5 22.1 1.0 O3A A:GDP506 4.5 15.2 1.0 CA A:ARG118 4.6 22.6 1.0 CB A:ARG118 4.6 23.8 1.0 CA A:ARG77 4.7 14.4 1.0 CA A:THR120 4.7 18.6 1.0 CA A:GLY149 4.7 15.7 1.0 C A:PHE76 4.7 17.4 1.0 CA A:GLU119 4.8 22.7 1.0 C A:GLU119 4.8 23.6 1.0 C A:ARG118 4.8 21.0 1.0 CE A:LYS80 5.0 14.3 1.0 CB A:GLU119 5.0 22.5 1.0

Aluminium binding site 2 out of 2 in the Human ATL1 Mutant - F151S Bound to GDPALF4-


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Human ATL1 Mutant - F151S Bound to GDPALF4- within 5.0Å range: probe atom residue distance (Å) B Occ B:Al507 b:22.9 occ:1.00 AL B:ALF507 0.0 22.9 1.0 F2 B:ALF507 1.8 25.1 1.0 F1 B:ALF507 1.8 23.5 1.0 F4 B:ALF507 1.8 26.1 1.0 F3 B:ALF507 1.8 23.9 1.0 O3B B:GDP506 2.0 24.9 1.0 O B:HOH646 2.1 20.8 1.0 PB B:GDP506 3.2 20.5 1.0 MG B:MG505 3.5 23.4 1.0 O2B B:GDP506 3.6 19.8 1.0 N B:ARG77 3.8 19.6 1.0 O1B B:GDP506 3.8 17.9 1.0 O B:HOH665 3.9 22.4 1.0 NH2 B:ARG77 4.0 19.2 1.0 N B:THR120 4.0 29.0 1.0 NZ B:LYS80 4.1 17.5 1.0 NE B:ARG77 4.1 21.1 1.0 N B:GLU119 4.1 22.7 1.0 N B:GLY149 4.1 21.4 1.0 O B:HOH744 4.1 18.6 1.0 OG1 B:THR120 4.2 22.8 1.0 CB B:THR120 4.3 20.4 1.0 CB B:PHE76 4.4 25.4 1.0 O B:THR120 4.4 24.2 1.0 O3A B:GDP506 4.4 20.5 1.0 CA B:PHE76 4.4 17.2 1.0 O B:HOH681 4.5 20.7 1.0 CZ B:ARG77 4.5 24.2 1.0 CA B:ARG77 4.6 20.2 1.0 CA B:GLY149 4.6 21.9 1.0 CA B:ARG118 4.6 25.6 1.0 CA B:THR120 4.7 23.0 1.0 CB B:ARG118 4.7 25.5 1.0 C B:PHE76 4.7 19.3 1.0 CE B:LYS80 4.8 12.5 1.0 C B:GLU119 4.8 34.9 1.0 CA B:GLU119 4.9 25.3 1.0 C B:ARG118 4.9 29.7 1.0 CB B:GLU119 5.0 21.4 1.0

J.P.O'donnell, L.J.Byrnes, R.B.Cooley, H.Sondermann. A Hereditary Spastic Paraplegia-Associated Atlastin Variant Exhibits Defective Allosteric Coupling in the Catalytic Core. J. Biol. Chem. V. 293 687 2018.
ISSN: ESSN 1083-351X
PubMed: 29180453
DOI: 10.1074/JBC.RA117.000380