Aluminium in PDB 6k7k: Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State)

All present enzymatic activity of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State):
7.6.2.1;

The structure of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Magnesium	(Mg)	2 atoms

The binding sites of Aluminium atom in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) (pdb code 6k7k). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total only one binding site of Aluminium was determined in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State), PDB code: 6k7k:

Aluminium binding site 1 out of 1 in the Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State)


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Cryo-Em Structure of the Human P4-Type Flippase ATP8A1-CDC50 (E1-Adp- Pi State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Al1202 b:65.5 occ:1.00 AL A:ALF1202 0.0 65.5 1.0 F4 A:ALF1202 1.8 65.5 1.0 F3 A:ALF1202 1.8 65.5 1.0 F1 A:ALF1202 1.8 65.5 1.0 F2 A:ALF1202 1.8 65.5 1.0 O1B A:ADP1201 2.5 0.8 1.0 OD2 A:ASP409 2.6 57.9 1.0 OD1 A:ASP409 2.6 57.9 1.0 CG A:ASP409 2.9 57.9 1.0 MG A:MG1204 3.4 60.6 1.0 OD1 A:ASN789 3.5 61.5 1.0 PB A:ADP1201 3.8 0.8 1.0 ND2 A:ASN789 3.9 61.5 1.0 O A:THR411 3.9 62.8 1.0 CG A:ASN789 4.1 61.5 1.0 O2B A:ADP1201 4.1 0.8 1.0 OD2 A:ASP790 4.2 55.6 1.0 O3A A:ADP1201 4.4 0.8 1.0 CB A:ASP409 4.4 57.9 1.0 OD1 A:ASP790 4.5 55.6 1.0 N A:THR411 4.6 62.8 1.0 CB A:THR411 4.6 62.8 1.0 NZ A:LYS766 4.7 66.6 1.0 CG A:ASP790 4.8 55.6 1.0 C A:THR411 4.9 62.8 1.0 N A:LYS410 4.9 66.2 1.0 CA A:THR411 4.9 62.8 1.0 OD1 A:ASP786 5.0 53.8 1.0 O3B A:ADP1201 5.0 0.8 1.0

M.Hiraizumi, K.Yamashita, T.Nishizawa, O.Nureki. Cryo-Em Structures Capture the Transport Cycle of the P4-Atpase Flippase. Science V. 365 1149 2019.
ISSN: ESSN 1095-9203
PubMed: 31416931
DOI: 10.1126/SCIENCE.AAY3353