Aluminium in PDB 7re3: Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer:
2.7.7.48; 3.6.4.12; 3.6.4.13;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Zinc	(Zn)	16 atoms
Magnesium	(Mg)	6 atoms

The binding sites of Aluminium atom in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer (pdb code 7re3). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total 4 binding sites of Aluminium where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer, PDB code: 7re3:
Jump to Aluminium binding site number: 1; 2; 3; 4;

Aluminium binding site 1 out of 4 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer within 5.0Å range: probe atom residue distance (Å) B Occ E:Al706 b:322.7 occ:1.00 AL E:AF3706 0.0 322.7 1.0 F3 E:AF3706 1.8 322.7 1.0 F2 E:AF3706 1.8 322.7 1.0 F1 E:AF3706 1.8 322.7 1.0 MG E:MG705 2.3 318.9 1.0 O3B E:ADP704 2.6 316.0 1.0 O1B E:ADP704 3.4 316.0 1.0 PB E:ADP704 3.5 316.0 1.0 OG E:SER289 3.9 311.6 1.0 O1A E:ADP704 4.1 316.0 1.0 NE2 E:GLN404 4.3 322.3 1.0 OE1 E:GLN404 4.5 322.3 1.0 CE E:LYS288 4.5 313.1 1.0 CA E:GLY538 4.5 353.4 1.0 O3A E:ADP704 4.6 316.0 1.0 NZ E:LYS288 4.6 313.1 1.0 O2B E:ADP704 4.6 316.0 1.0 CD E:GLN404 4.8 322.3 1.0 NH1 E:ARG443 4.9 350.2 1.0 N E:GLY285 4.9 324.2 1.0 PA E:ADP704 4.9 316.0 1.0

Aluminium binding site 2 out of 4 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer within 5.0Å range: probe atom residue distance (Å) B Occ F:Al1005 b:194.8 occ:1.00 AL F:AF31005 0.0 194.8 1.0 F1 F:AF31005 1.8 194.8 1.0 F3 F:AF31005 1.8 194.8 1.0 F2 F:AF31005 1.8 194.8 1.0 N F:GLY285 2.7 193.3 1.0 O1B F:ADP1003 2.7 194.2 1.0 NZ F:LYS288 3.0 189.9 1.0 O3B F:ADP1003 3.2 194.2 1.0 PB F:ADP1003 3.3 194.2 1.0 CA F:PRO284 3.4 191.6 1.0 C F:PRO284 3.5 191.6 1.0 CE F:LYS288 3.6 189.9 1.0 O F:PRO283 3.6 189.9 1.0 CA F:GLY285 3.7 193.3 1.0 O2B F:ADP1003 3.9 194.2 1.0 N F:THR286 4.0 191.8 1.0 N F:PRO284 4.3 191.6 1.0 C F:PRO283 4.3 189.9 1.0 C F:GLY285 4.3 193.3 1.0 CB F:PRO284 4.4 191.6 1.0 OG1 F:THR286 4.5 191.8 1.0 O F:PRO284 4.7 191.6 1.0 O3A F:ADP1003 4.8 194.2 1.0

Aluminium binding site 3 out of 4 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 3 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer within 5.0Å range: probe atom residue distance (Å) B Occ K:Al706 b:422.9 occ:1.00 AL K:AF3706 0.0 422.9 1.0 F3 K:AF3706 1.8 422.9 1.0 F2 K:AF3706 1.8 422.9 1.0 F1 K:AF3706 1.8 422.9 1.0 MG K:MG705 2.3 418.4 1.0 O3B K:ADP704 2.6 417.9 1.0 O2B K:ADP704 3.4 417.9 1.0 PB K:ADP704 3.5 417.9 1.0 OG K:SER289 3.9 412.2 1.0 O2A K:ADP704 4.1 417.9 1.0 NE2 K:GLN404 4.3 414.8 1.0 OE1 K:GLN404 4.5 414.8 1.0 CE K:LYS288 4.5 413.4 1.0 CA K:GLY538 4.5 451.8 1.0 O3A K:ADP704 4.6 417.9 1.0 NZ K:LYS288 4.6 413.4 1.0 O1B K:ADP704 4.6 417.9 1.0 CD K:GLN404 4.8 414.8 1.0 NH1 K:ARG443 4.9 452.7 1.0 N K:GLY285 4.9 426.8 1.0 PA K:ADP704 4.9 417.9 1.0

Aluminium binding site 4 out of 4 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 4 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(2)-Rtc Dimer within 5.0Å range: probe atom residue distance (Å) B Occ L:Al1005 b:201.6 occ:1.00 AL L:AF31005 0.0 201.6 1.0 F1 L:AF31005 1.8 201.6 1.0 F3 L:AF31005 1.8 201.6 1.0 F2 L:AF31005 1.8 201.6 1.0 N L:GLY285 2.7 199.2 1.0 O2B L:ADP1003 2.7 201.2 1.0 NZ L:LYS288 3.0 195.9 1.0 O3B L:ADP1003 3.2 201.2 1.0 PB L:ADP1003 3.3 201.2 1.0 CA L:PRO284 3.4 198.5 1.0 C L:PRO284 3.5 198.5 1.0 CE L:LYS288 3.6 195.9 1.0 O L:PRO283 3.6 196.7 1.0 CA L:GLY285 3.7 199.2 1.0 O1B L:ADP1003 3.9 201.2 1.0 N L:THR286 4.0 199.1 1.0 N L:PRO284 4.3 198.5 1.0 C L:PRO283 4.3 196.7 1.0 C L:GLY285 4.3 199.2 1.0 CB L:PRO284 4.4 198.5 1.0 OG1 L:THR286 4.5 199.1 1.0 O L:PRO284 4.7 198.5 1.0 O3A L:ADP1003 4.8 201.2 1.0

J.Chen, Q.Wang, B.Malone, E.C.Llewellyn, K.Maruthi, E.T.Eng, J.Perry, E.A.Campbell, D.E.Shaw, S.A.Darst. Ensemble Cryo-Electron Microscopy Reveals Conformational States of the Sars-Cov-2 Helicase Replication-Transcription Complex Biorxiv 2021.
DOI: 10.1101/2021.11.10.468168