Aluminium in PDB 8iwu: HSPCA1 in the E2~P State

All present enzymatic activity of HSPCA1 in the E2~P State:
7.2.2.10;

The structure of HSPCA1 in the E2~P State also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Fluorine	(F)	4 atoms

The binding sites of Aluminium atom in the HSPCA1 in the E2~P State (pdb code 8iwu). This binding sites where shown within 5.0 Angstroms radius around Aluminium atom.
In total only one binding site of Aluminium was determined in the HSPCA1 in the E2~P State, PDB code: 8iwu:

Aluminium binding site 1 out of 1 in the HSPCA1 in the E2~P State


Mono view


Stereo pair view

A full contact list of Aluminium with other atoms in the Al binding site number 1 of HSPCA1 in the E2~P State within 5.0Å range: probe atom residue distance (Å) B Occ A:Al1002 b:39.1 occ:1.00 AL A:ALF1002 0.0 39.1 1.0 F4 A:ALF1002 1.8 35.4 1.0 F1 A:ALF1002 1.8 10.5 1.0 F2 A:ALF1002 1.8 42.8 1.0 F3 A:ALF1002 1.8 51.2 1.0 OD2 A:ASP350 2.7 31.0 1.0 OD1 A:ASP350 2.8 40.4 1.0 CG A:ASP350 3.1 37.5 1.0 O A:THR189 3.3 39.4 1.0 MG A:MG1001 3.8 5.8 1.0 OD2 A:ASP648 4.0 44.1 1.0 NZ A:LYS625 4.1 10.8 1.0 OD1 A:ASP648 4.2 45.0 1.0 N A:GLY571 4.3 45.9 1.0 CB A:THR352 4.3 26.7 1.0 CA A:GLY190 4.3 38.2 1.0 O A:GLY190 4.4 36.8 1.0 C A:THR189 4.5 38.0 1.0 CA A:GLY571 4.5 36.5 1.0 C A:GLY190 4.5 39.3 1.0 CG A:ASP648 4.5 41.1 1.0 CB A:ASP350 4.6 27.1 1.0 OG1 A:THR352 4.6 30.9 1.0 ND2 A:ASN647 4.7 28.1 1.0 CG A:GLU191 4.8 39.2 1.0 OE2 A:GLU191 4.8 47.6 1.0 N A:GLY190 4.9 45.3 1.0 N A:THR352 4.9 24.3 1.0

M.Wu, C.Wu, T.Song, K.Pan, Y.Wang, Z.Liu. Structure and Transport Mechanism of the Human Calcium Pump SPCA1. Cell Res. V. 33 533 2023.
ISSN: ISSN 1001-0602
PubMed: 37258749
DOI: 10.1038/S41422-023-00827-X